An efficient one-pot synthesis of novel 4-aryl-1-methyloxindoles

An unprecedented synthetic approach to novel 4-aryl-1-methyloxindoles is described. The method involves the intramolecular palladium-catalyzed amidation of N-methyl-2,6-dibromophenylacetamide followed by an in situ Suzuki cross-coupling reaction with a (hetero)arylboronic acid in a one-pot reaction.

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Bibliographic Details
Published in:Tetrahedron letters 2006-06, Vol.47 (26), p.4361-4364
Main Authors: van den Hoogenband, Adri, Lange, Jos H.M., Iwema-Bakker, Wouter I., den Hartog, Jack A.J., van Schaik, Jord, Feenstra, Rolf W., Terpstra, Jan Willem
Format: Article
Language:English
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Description
Summary:An unprecedented synthetic approach to novel 4-aryl-1-methyloxindoles is described. The method involves the intramolecular palladium-catalyzed amidation of N-methyl-2,6-dibromophenylacetamide followed by an in situ Suzuki cross-coupling reaction with a (hetero)arylboronic acid in a one-pot reaction.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.04.103