Effect of microwave heating on Ullmann-type heterocycle-aryl ether synthesis using chloro-heterocycles

Ullmann ether synthesis was conducted on a variety of chloro-heterocycles with different phenols using optimized conditions involving copper powder and cesium carbonate. On many substrates, microwave heating afforded higher yields in significantly shorter reaction times compared to conventional heat...

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Bibliographic Details
Published in:Tetrahedron letters 2006-07, Vol.47 (29), p.5045-5048
Main Authors: D’Angelo, Noel D., Peterson, Joseph J., Booker, Shon K., Fellows, Ingrid, Dominguez, Celia, Hungate, Randall, Reider, Paul J., Kim, Tae-Seong
Format: Article
Language:English
Subjects:
Microwave
Ullmann ether synthesis
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Summary:Ullmann ether synthesis was conducted on a variety of chloro-heterocycles with different phenols using optimized conditions involving copper powder and cesium carbonate. On many substrates, microwave heating afforded higher yields in significantly shorter reaction times compared to conventional heating conditions. These findings provide a facile method for aryl ether synthesis from chloropyridines, chloroquinolines, and chlorobenzothiazoles. Ullmann ether synthesis was conducted on a variety of chloro-heterocycles with different phenols using optimized conditions involving copper powder and cesium carbonate. On many substrates, microwave heating afforded higher yields in significantly shorter reaction times compared to conventional heating conditions. These findings provide a facile method for aryl ether synthesis from chloropyridines, chloroquinolines, and chlorobenzothiazoles.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.05.103