An efficient approach toward the synthesis of the A/B rings of ouabain

The synthesis of the highly functionalized A/B ring related to ouabain has been accomplished efficiently from commercially available α-tetralone. A key Birch reductive alkylation allows the building of an angularly substituted decalone that was adequately functionalized to produce the intermediate 2...

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Bibliographic Details
Published in:Tetrahedron letters 2006-10, Vol.47 (42), p.7447-7449
Main Authors: Plano, María Fernanda, Labadie, Guillermo R., Sierra, Manuel Gonzalez, Cravero, Raquel M.
Format: Article
Language:English
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Summary:The synthesis of the highly functionalized A/B ring related to ouabain has been accomplished efficiently from commercially available α-tetralone. A key Birch reductive alkylation allows the building of an angularly substituted decalone that was adequately functionalized to produce the intermediate 2c.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.08.047