Kinetic resolution of d, l-1,2-diols catalyzed by amine-phosphinite bifunctional organocatalysis derived from quinidine

Racemic C 2-symmetric 1,2-diols were kinetically resolved by the acylation reaction catalyzed by the phosphinite derivative of quinidine to afford the corresponding monoacylated product with good to high enantioselectivities.

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Bibliographic Details
Published in:Tetrahedron letters 2006-11, Vol.47 (47), p.8227-8229
Main Authors: Mizuta, Shinya, Ohtsubo, Yutaka, Tsuzuki, Takeo, Fujimoto, Tetsuya, Yamamoto, Iwao
Format: Article
Language:English
Subjects:
1,2-Diol
Cinchona alkaloid
Kinetic resolution
Organocatalyst
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Description
Summary:Racemic C 2-symmetric 1,2-diols were kinetically resolved by the acylation reaction catalyzed by the phosphinite derivative of quinidine to afford the corresponding monoacylated product with good to high enantioselectivities.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.09.109