Synthesis of functionalized benzimidazoles and quinoxalines catalyzed by sodium hexafluorophosphate bound Amberlite resin in aqueous medium

A very simple, eco-friendly, and versatile method for the selective synthesis of 1,2-disubstituted benzimidazoles and quinoxalines in water–methanol (1:1) with the aid of resin bound hexafluorophosphate ion as catalyst is reported. A very simple, eco-friendly, and versatile method for the selective...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2012-11, Vol.53 (48), p.6483-6488
Main Authors: Ghosh, Pranab, Mandal, Amitava
Format: Article
Language:English
Subjects:
Benzimidazole
Friedelin
Hexafluorophosphate ion
Quinoxaline
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A very simple, eco-friendly, and versatile method for the selective synthesis of 1,2-disubstituted benzimidazoles and quinoxalines in water–methanol (1:1) with the aid of resin bound hexafluorophosphate ion as catalyst is reported. A very simple, eco-friendly, and versatile method for the selective synthesis of 1,2-disubstituted benzimidazoles and quinoxalines in water–methanol (1:1) mixture with the aid of resin bound hexafluorophosphate ion as catalyst is reported. The method is also effective for the incorporation of quinoxaline nucleus at the A ring of pentacyclic triterpenoid, friedelin. A plausible mechanism for the formation of disubstituted benzimidazole has also been suggested.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.09.045