Expedient stereoselective synthesis of new dihydropyrano- and dihydrofuranonaphthoquinones

[Display omitted] Heterocyclic naphthoquinones represent valuable scaffolds in medicinal chemistry. In the present Letter, the efficient stereoselective synthesis of new dihydropyrano- and dihydrofuranonaphthoquinones by means of one-pot multicomponent reactions using 2-hydroxy-1,4-naphthoquinone, a...

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Bibliographic Details
Published in:Tetrahedron letters 2015-05, Vol.56 (19), p.2422-2425
Main Authors: Dang Thi, Tuyet Anh, Depetter, Yves, Mollet, Karen, Thi Phuong, Hoang, Vu Ngoc, Doan, Pham The, Chinh, Thanh Nguyen, Ha, Nguyen Thi, Thu Ha, Huy Nguyen, Hung, D’hooghe, Matthias, Van Nguyen, Tuyen
Format: Article
Language:English
Subjects:
2-Hydroxy-1,4-napthoquinones
Furanonaphthoquinones
Multicomponent reactions
Pyranonaphthoquinones
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Summary:[Display omitted] Heterocyclic naphthoquinones represent valuable scaffolds in medicinal chemistry. In the present Letter, the efficient stereoselective synthesis of new dihydropyrano- and dihydrofuranonaphthoquinones by means of one-pot multicomponent reactions using 2-hydroxy-1,4-naphthoquinone, an aromatic aldehyde and ethyl 4,4,4-trifluoroacetoacetate or a pyridinium bromide, respectively, is described.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2015.03.071