Isopropanol and potassium tert-butoxide promoted intramolecular direct sp2 C–H functionalization: an expedient synthesis of 1,2,3-triazole annulated chromens and quinolones

[Display omitted] A series of 1,2,3-triazole annulated chromen and quinolone derivatives have been synthesized by means of direct sp2 C–H functionalization in the presence of iso-propanol and potassium tert-butoxide. The reaction proceeds through homolytic aromatic substitution (HAS). This efficient...

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Bibliographic Details
Published in:Tetrahedron letters 2015-10, Vol.56 (44), p.6123-6127
Main Authors: Mondal, Biplab, Roy, Brindaban
Format: Article
Language:English
Subjects:
1,2,3-Triazole
Heterocycles
Intramolecular C–C coupling
Iso-propanol
Potassium tert-butoxide
sp2 C–H functionalization
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Summary:[Display omitted] A series of 1,2,3-triazole annulated chromen and quinolone derivatives have been synthesized by means of direct sp2 C–H functionalization in the presence of iso-propanol and potassium tert-butoxide. The reaction proceeds through homolytic aromatic substitution (HAS). This efficient as well as simple C–H functionalization methodology offers a straightforward route to 1,2,3-triazole annulated oxygen and nitrogen heterocycles.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2015.09.096