Direct sulfonylation of pyrazolones with sodium sulfinates catalyzed by TBAI in water

[Display omitted] •Reactions can be carried out using water as solvent.•Different reaction mechanism from previous reports.•An equivalent amount of iodine reagents was not needed. An efficient sulfonylation reaction of pyrazolones with sodium sulfinates catalyzed by TBAI was established. A wide vari...

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Bibliographic Details
Published in:Tetrahedron letters 2018-04, Vol.59 (15), p.1517-1520
Main Authors: Li, Li-Xia, Dong, Dao-Qing, Hao, Shuang-Hong, Wang, Zu-Li
Format: Article
Language:English
Subjects:
C–H functionalization
Pyrazolones
Sulfonylation
TBAI
Water
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Summary:[Display omitted] •Reactions can be carried out using water as solvent.•Different reaction mechanism from previous reports.•An equivalent amount of iodine reagents was not needed. An efficient sulfonylation reaction of pyrazolones with sodium sulfinates catalyzed by TBAI was established. A wide variety of valuable sulfonated pyrazolones were obtained in good to excellent yields using water as solvent.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2018.03.023