Room temperature dehalogenation of (hetero)aryl halides with magnesium/methanol

[Display omitted] •(Hetero)aryl halides are efficiently dehalogenated with magnesium in methanol.•Various functional groups are tolerated under mild conditions.•Iodo-, bromo- and chloro-derivatives are good substrates.•This dehalogenation method represents a trustworthy alternative to other approach...

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Bibliographic Details
Published in:Tetrahedron letters 2018-08, Vol.59 (32), p.3108-3111
Main Authors: Jouha, Jabrane, Khouili, Mostafa, Hiebel, Marie-Aude, Guillaumet, Gérald, Suzenet, Franck
Format: Article
Language:English
Subjects:
Aryl halides
Dehalogenation
Heteroaryl halides
Magnesium
Methanol
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Summary:[Display omitted] •(Hetero)aryl halides are efficiently dehalogenated with magnesium in methanol.•Various functional groups are tolerated under mild conditions.•Iodo-, bromo- and chloro-derivatives are good substrates.•This dehalogenation method represents a trustworthy alternative to other approaches already reported. Magnesium in methanol was found to be an effective and inexpensive reagent for the dehalogenation of (hetero)aryl chlorides, bromides and iodides under mild conditions. The halogen/hydrogen exchange proceeded at room temperature and tolerated functional groups such as esters, nitriles, alcohols, and alkenes.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2018.07.008