Nickel catalyzed deoxygenative cross-coupling of benzyl alcohols with aryl-bromides

[Display omitted] •The direct nickel catalyzed cross-coupling of benzyl alcohols.•Cross-electrophile coupling of aryl bromides with benzyl alcohols under mild conditions.•Synthesis of diarylmethanes and 1,3-diarylpropenes from alcohols. A nickel-catalyzed cross-electrophile coupling of benzyl alcoho...

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Bibliographic Details
Published in:Tetrahedron letters 2020-04, Vol.61 (14), p.151729, Article 151729
Main Authors: Kumar Chenniappan, Vinoth, Peck, Devin, Rahaim, Ronald
Format: Article
Language:English
Subjects:
Alcohol
Cross-electrophile coupling
Diarylmethane
Nickel cross-coupling
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Summary:[Display omitted] •The direct nickel catalyzed cross-coupling of benzyl alcohols.•Cross-electrophile coupling of aryl bromides with benzyl alcohols under mild conditions.•Synthesis of diarylmethanes and 1,3-diarylpropenes from alcohols. A nickel-catalyzed cross-electrophile coupling of benzyl alcohols with aromatic bromides has been developed. This deoxygenative cross-coupling occurs under mild reaction conditions at ambient temperature affording diarylmethanes, or 1,3-diarylpropenes from benzyl allyl alcohols. The system demonstrated good chemoselectivity tolerating an assortment of reactive functional groups.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2020.151729