Dihydropyracyloporphyrins

[Display omitted] A pyrrole ethyl ester with a fused dihydropyracylene unit was prepared by reacting 5-nitro-1,2-dihydropyracylene with ethyl isocyanoacetate in the presence of a phosphazene base. Cleavage of the ester moiety, followed by reaction with an acetoxymethylpyrrole and acetic acid in refl...

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Bibliographic Details
Published in:Tetrahedron letters 2020-12, Vol.61 (52), p.152662, Article 152662
Main Authors: Rauen, Patrick J., Lash, Timothy D.
Format: Article
Language:English
Subjects:
Annelated porphyrins
Barton-Zard reaction
Conformational analysis
Pyracylene
‘3 + 1’ condensations
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Summary:[Display omitted] A pyrrole ethyl ester with a fused dihydropyracylene unit was prepared by reacting 5-nitro-1,2-dihydropyracylene with ethyl isocyanoacetate in the presence of a phosphazene base. Cleavage of the ester moiety, followed by reaction with an acetoxymethylpyrrole and acetic acid in refluxing ethanol, afforded a tripyrrane, and subsequent ‘3 + 1’ condensation with a pyrrole dialdehyde gave a dihydropyracyloporphyrin. Cyclotetramerization of the dihydropyracylopyrrole with benzaldehyde and BF3·Et2O gave a sterically crowded tetrakis(dihydropyracylo)-porphyrin and the reduced five-membered rings proved to be an excellent NMR probe for conformational mobility. The new porphyrins and their nickel(II) complexes also showed potentially valuable highly red shifted UV–vis spectra.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2020.152662