New azaspirene derivatives from marine-derived fungus Aspergillus micronesiensis NF666

[Display omitted] Azaspirene derivatives are widespread natural products in fungi. Here we reported five new azaspirenes A-E (1–5) from the marine mud-derived endophytic fungus Aspergillus micronesiensis NF666. Their structures were unambiguously determined by an extensive analysis of HRESIMS and NM...

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Published in:Tetrahedron letters 2023-06, Vol.123, p.154566, Article 154566
Main Authors: Jiao, Fang Wen, Xing, Yin Nan, Liu, Tian Yu, Wu, Feng, Li, Wei, Jiao, Rui Hua
Format: Article
Language:English
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Azaspirene derivatives
Biosynthesis
Endophytic fungus
Structure elucidation
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Liu, Tian Yu
Wu, Feng
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Jiao, Rui Hua
description [Display omitted] Azaspirene derivatives are widespread natural products in fungi. Here we reported five new azaspirenes A-E (1–5) from the marine mud-derived endophytic fungus Aspergillus micronesiensis NF666. Their structures were unambiguously determined by an extensive analysis of HRESIMS and NMR data. All compounds were evaluated on antimicrobial activities against five pathogens by the agar diffusion method. Moreover, a plausible biosynthetic pathway of azaspirenes A (1) is proposed in this work.
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subjects Azaspirene derivatives
Biosynthesis
Endophytic fungus
Structure elucidation
title New azaspirene derivatives from marine-derived fungus Aspergillus micronesiensis NF666
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