Lower limits of detection in speciation analysis by coupling high-performance liquid chromatography and chemical-vapor generation

Speciation studies are much more important than total element determination because toxicity of many elements depends on their chemical forms. Nobody can claim that a foodstuff is very dangerous to eat by determining total arsenic due to the possibility that the arsenic could be present in non-toxic...

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Bibliographic Details
Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2011-04, Vol.30 (4), p.569-585
Main Authors: Arslan, Yasin, Yildirim, Emrah, Gholami, Mehrdad, Bakirdere, Sezgin
Format: Article
Language:English
Subjects:
Analytical chemistry
Arsenic
Atomic absorption spectrometry
Atomic fluorescence spectroscopy
Chemical-vapor generation
Chemistry
Chromatographic methods and physical methods associated with chromatography
detection limit
Exact sciences and technology
foods
High-performance liquid chromatography
humans
Inductively coupled plasma mass spectrometry
Limit of detection
On-line oxidation/reduction
Other chromatographic methods
Speciation
Spectrometric and optical methods
toxicity
Trace element
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Summary:Speciation studies are much more important than total element determination because toxicity of many elements depends on their chemical forms. Nobody can claim that a foodstuff is very dangerous to eat by determining total arsenic due to the possibility that the arsenic could be present in non-toxic forms. Hence, speciation studies are crucial in any matrix relevant to human beings. Trace-element speciation requires sufficiently sensitive procedures to monitor each species at trace levels. One way to increase the sensitivity for elements forming volatile species is coupling high-performance liquid chromatography (HPLC) with chemical-vapor generation (CVG). This review aims to highlight not only development of HPLC-CVG techniques for ultratrace-elemental speciation in a variety of matrices but also their application. In addition, we discuss the advantages and the disadvantages of these techniques.
ISSN:0165-9936
1879-3142
DOI:10.1016/j.trac.2010.11.017