Dermatopathology of skin cancer in solid organ transplant recipients

Abstract Skin cancers occur more frequently in solid organ transplant recipients relative to the general population. Transplant recipients are at particularly high risk of squamous cell carcinoma, with up to a 100-fold increase in the relative risk when compared to the nontransplanted population. Th...

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Bibliographic Details
Published in:Transplantation reviews (Philadelphia, Pa.) Pa.), 2010-10, Vol.24 (4), p.172-189
Main Authors: Stoff, Benjamin, Salisbury, Catherine, Parker, Douglas, O'Reilly Zwald, Fiona
Format: Article
Language:English
Subjects:
Carcinoma, Basal Cell - etiology
Carcinoma, Merkel Cell - etiology
Carcinoma, Squamous Cell - epidemiology
Carcinoma, Squamous Cell - etiology
Humans
Keratosis, Actinic - etiology
Kidney Transplantation - adverse effects
Lymphoproliferative Disorders - etiology
Organ Transplantation - adverse effects
Porokeratosis - epidemiology
Porokeratosis - etiology
Risk Assessment
Sarcoma, Kaposi - epidemiology
Skin - pathology
Skin Neoplasms - epidemiology
Skin Neoplasms - etiology
Skin Neoplasms - pathology
Skin Neoplasms - therapy
Surgery
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Summary:Abstract Skin cancers occur more frequently in solid organ transplant recipients relative to the general population. Transplant recipients are at particularly high risk of squamous cell carcinoma, with up to a 100-fold increase in the relative risk when compared to the nontransplanted population. This compares with a 10- to 16-fold increase in basal cell carcinoma for renal transplant recipients. An increased incidence of melanoma in transplant patients has also been reported. Other types of skin cancer associated with immunosuppression in transplant patients include Kaposi sarcoma, Merkel cell carcinoma, and posttransplant lymphoproliferative disorder. This review discusses the epidemiology and pertinent pathologic features of each of these tumors. A brief clinical management strategy is outlined. In addition, the contribution of viral induced carcinogenesis with respect to Kaposi sarcoma, Merkel cell carcinoma, and posttransplant lymphoproliferative disorder is discussed.
ISSN:0955-470X
1557-9816
DOI:10.1016/j.trre.2010.05.002