Early origins of ethnic disparities in cardiovascular risk factors

Abstract Background Not much is known about the ethnic differences in cardiovascular risk factors during childhood in European countries. We examined the ethnic differences in childhood cardiovascular risk factors in the Netherlands. Methods In a multi-ethnic population-based prospective cohort stud...

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Bibliographic Details
Published in:Preventive medicine 2015-07, Vol.76, p.84-91
Main Authors: Gishti, Olta, Gaillard, Romy, Felix, Janine F, Bouthoorn, Selma, Steegers, Eric, Raat, Hein, Hofman, Albert, Duijts, Liesbeth, Franco, Oscar H, Jaddoe, Vincent W.V
Format: Article
Language:English
Subjects:
Body Mass Index
Cabo Verde - ethnology
Cardiovascular Diseases - ethnology
Child
Child Development - physiology
Child, Preschool
Ethnicity
Female
Health Status Disparities
Humans
Hypertension
Insulin
Internal Medicine
Lipids
Lipids - blood
Male
Netherlands
Pediatrics
Prospective Studies
Risk Factors
Suriname - ethnology
Turkey - ethnology
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Summary:Abstract Background Not much is known about the ethnic differences in cardiovascular risk factors during childhood in European countries. We examined the ethnic differences in childhood cardiovascular risk factors in the Netherlands. Methods In a multi-ethnic population-based prospective cohort study, we measured blood pressure, left ventricular mass, and levels of cholesterol, triglyceride and insulin at the median age of 6.2 years. Results As compared to Dutch children, Cape Verdean and Turkish children had a higher blood pressure, whereas Cape Verdean, Surinamese-Creole and Turkish children had higher total-cholesterol levels (p-values < 0.05). Turkish children had higher triglyceride levels, but lower insulin levels than Dutch children (p-values < 0.05). As compared to Dutch children, only Turkish children had an increased risk of clustering of cardiovascular risk factors (odds ratio: 2.45 (95% confidence interval 1.18, 3.37)). Parental pre-pregnancy factors explained up to 50% of the ethnic differences in childhood risk factors. In addition to these factors, pregnancy and childhood factors and childhood BMI explained up to 50%, 12.5% and 61.1%, respectively. Conclusions Our results suggest that compared to Dutch children, Cape Verdean, Surinamese-Creole and Turkish children have an adverse cardiovascular profile. These differences are largely explained by parental pre-pregnancy factors, pregnancy factors and childhood BMI.
ISSN:0091-7435
1096-0260
DOI:10.1016/j.ypmed.2015.03.027