Fe-T 1 Sensor Based on Coordination Chemistry for Sensitive and Versatile Bioanalysis

The main challenge of paramagnetic ions-mediated magnetic sensors is their relatively low sensitivity. In this study, we observe the amplification of longitudinal relaxation time (T ) signal when Fe transforms into Fe followed by the coordination of potassium thiocyanate (KSCN) and develop a sensiti...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2018-08, Vol.90 (15), p.9148-9155
Main Authors: Dong, Mingling, Zheng, Wenshu, Chen, Yiping, Xianyu, Yunlei, Ran, Bei, Qian, Zhiyong, Jiang, Xingyu
Format: Article
Language:English
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Summary:The main challenge of paramagnetic ions-mediated magnetic sensors is their relatively low sensitivity. In this study, we observe the amplification of longitudinal relaxation time (T ) signal when Fe transforms into Fe followed by the coordination of potassium thiocyanate (KSCN) and develop a sensitive Fe-T sensor based on the coordination chemistry between KSCN and Fe to amplify the T signal for detecting a series of targets, such as hydrogen peroxide, glucose, and antigen/antibody. We justify the practicability of our assay by successfully detecting tetracycline in milk samples and hepatitis C virus in clinical samples with satisfactory accuracy. This KSCN-mediated Fe-T sensor not only realizes biochemical analysis and immunoassay with higher sensitivity but also retains many advantages of paramagnetic ions-mediated magnetic sensors (good stability and straightforward operation), which holds great promise for the detection of a range of targets of interest in complex samples.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.8b01577