Polydopamine Coated PB-MnO 2 Nanoparticles as an Oxygen Generator Nanosystem for Imaging-Guided Single-NIR-Laser Triggered Synergistic Photodynamic/Photothermal Therapy

Exploring a combined phototherapeutic strategy to overcome the limitations of a single mode therapy and inducing high anticancer efficiency is highly promising for precision cancer nanomedicine. However, a single-wavelength laser activates dual photothermal/photodynamic therapy (PTT/PDT) treatment i...

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Published in:Bioconjugate chemistry 2020-05, Vol.31 (5), p.1474-1485
Main Authors: Odda, Atheer Hameid, Li, Hailiang, Kumar, Naveen, Ullah, Naseeb, Khan, Malik Ihsanullah, Wang, Gang, Liang, Kuang, Liu, Tan, Pan, Yue-Yin, Xu, An-Wu
Format: Article
Language:English
Subjects:
Cell Line, Tumor
Drug Design
Ferrocyanides - chemistry
Humans
Indoles - chemistry
Indoles - pharmacology
Infrared Rays
Lasers
Manganese Compounds - chemistry
Nanoparticles - chemistry
Oxides - chemistry
Oxygen - metabolism
Photochemotherapy - methods
Polymers - chemistry
Polymers - pharmacology
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Summary:Exploring a combined phototherapeutic strategy to overcome the limitations of a single mode therapy and inducing high anticancer efficiency is highly promising for precision cancer nanomedicine. However, a single-wavelength laser activates dual photothermal/photodynamic therapy (PTT/PDT) treatment is still a formidable challenge. Herein, we strategically design and fabricate a multifunctional theranostic nanosystem based on chlorin e6-functionalized polydopamine (PDA) coated prussian blue/manganese dioxide nanoparticles (PB-MnO @PDA-Ce6 NPs). Interestingly, the obtained PB-MnO @PDA NPs not only offer an effective delivery system for Ce6 but also provide strong optical absorption in the near-infrared range, endowing high antitumor efficacy of PTT. More importantly, the as-prepared PB-MnO @PDA-Ce6 nanoagents exhibit an effective oxygen generation, superior reactive oxygen species (ROS), and outstanding photothermal conversion ability to greatly improve PTT and PDT treatments. As a result, both and treatments guided by MR imaging on liver cancer cells reveal the complete cell/tumor eradication under a single wavelength of 660 nm laser irradiation, implying the simultaneous synergistic PDT/PTT effects triggered by PB-MnO @PDA-Ce6 nanoplatform, which are much higher than individual treatment. Taken together, our phototherapeutic nanoagents exhibit an excellent therapeutic performance, which may act as a nanoplatform to find safe and clinically translatable routes to accelerate cancer therapeutics.
ISSN:1043-1802
1520-4812
DOI:10.1021/acs.bioconjchem.0c00165