Highly Stretchable and Conductive Self-Healing Hydrogels for Temperature and Strain Sensing and Chronic Wound Treatment

Flexible bioelectronics for biomedical applications requires a stretchable, conductive, self-healable, and biocompatible material that can be obtained by cost-effective chemicals and strategies. Herein, we synthesized polypyrrole or Zn-functionalized chitosan molecules, which are cross-linked with p...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2020-09, Vol.12 (37), p.40990-40999
Main Authors: Zhang, Jieyu, Wu, Can, Xu, Yuanyuan, Chen, Jiali, Ning, Ning, Yang, Zeyu, Guo, Yi, Hu, Xuefeng, Wang, Yunbing
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Biological and Medical Applications of Materials and Interfaces
Electric Conductivity
Electric Stimulation
Hydrogels - chemical synthesis
Hydrogels - chemistry
Hydrogels - pharmacology
Male
Microbial Sensitivity Tests
Particle Size
Pseudomonas aeruginosa - drug effects
Rats
Rats, Sprague-Dawley
Staphylococcus aureus - drug effects
Surface Properties
Temperature
Wound Healing - drug effects
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Summary:Flexible bioelectronics for biomedical applications requires a stretchable, conductive, self-healable, and biocompatible material that can be obtained by cost-effective chemicals and strategies. Herein, we synthesized polypyrrole or Zn-functionalized chitosan molecules, which are cross-linked with poly­(vinyl alcohol) to form a hydrogel through dynamic di-diol complexations, hydrogen bonding, and zinc-based coordination bonds. These multiple dynamic interactions endow the material with excellent stretchability and autonomous self-healing ability. The choice of Food and Drug Administration (FDA)-approved materials (poly­(vinyl alcohol) and chitosan) as the matrix materials ensures the good biocompatibility of the hydrogel. The conductivity contributed by the polypyrrole allowed the hydrogel to sense strain and temperature, and the coordinated Zn significantly enhanced the antibacterial activity of the hydrogel. Moreover, using a diabetic rat model, we have proved that this hydrogel is capable of promoting the healing of the infected chronic wounds with electrical stimulation.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.0c08291