Accessing Axially Chiral Biaryls via Organocatalytic Enantioselective Dynamic-Kinetic Resolution-Semipinacol Rearrangement

We have developed a synthetic strategy to access axially chiral biaryls through a dynamic-kinetic resolution-semipinacol rearrangement process. The axial chirality together with a sp3 quaternary carbon can be introduced in a single chemical operation. The products can be further ring-expanded to yie...

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Bibliographic Details
Published in:ACS catalysis 2017-07, Vol.7 (7), p.4435-4440
Main Authors: Liu, Yi, Tse, Ying-Lung Steve, Kwong, Fuk Yee, Yeung, Ying-Yeung
Format: Article
Language:English
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Summary:We have developed a synthetic strategy to access axially chiral biaryls through a dynamic-kinetic resolution-semipinacol rearrangement process. The axial chirality together with a sp3 quaternary carbon can be introduced in a single chemical operation. The products can be further ring-expanded to yield biologically relevant seven-membered dibenzolactams with inverted axial chirality.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.7b01056