Revisitation of Organoaluminum Reagents Affords a Versatile Protocol for C–X (X = N, O, F) Bond-Cleavage Cross-Coupling: A Systematic Study

A revisit of organoaluminum reagents for cross-coupling reactions has opened up several types of C–C bond formation protocols through cleavage of phenolic/alcoholic C–O and C–F and ammonium C–N bonds. Catalyzed by the commercially available NiCl2(PCy3)2 catalyst, these reactions proceed smoothly wit...

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Bibliographic Details
Published in:ACS catalysis 2017-06, Vol.7 (6), p.3988-3994
Main Authors: Ogawa, Hiroyuki, Yang, Ze-Kun, Minami, Hiroki, Kojima, Kumiko, Saito, Tatsuo, Wang, Chao, Uchiyama, Masanobu
Format: Article
Language:English
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Summary:A revisit of organoaluminum reagents for cross-coupling reactions has opened up several types of C–C bond formation protocols through cleavage of phenolic/alcoholic C–O and C–F and ammonium C–N bonds. Catalyzed by the commercially available NiCl2(PCy3)2 catalyst, these reactions proceed smoothly with a wide range of substrates and broad functional group compatibility, providing a versatile methodology for organoaluminum-mediated cross-coupling processes.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.7b01058