Direct Decarboxylative Meta-Selective Acylation of Arenes via an Ortho-Ruthenation Strategy

The direct decarboxylative meta-selective C–H acylation of a wide range of arenes is established via the ruthenium-catalyzed ortho-metalation strategy. This procedure, using Ru3(CO)12 as the catalyst and α-oxocarboxylic acids as the acylation source, featured broad substrate scope, good functional g...

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Bibliographic Details
Published in:ACS catalysis 2018-12, Vol.8 (12), p.11875-11881
Main Authors: Jing, Kun, Li, Zhong-Yuan, Wang, Guan-Wu
Format: Article
Language:English
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Summary:The direct decarboxylative meta-selective C–H acylation of a wide range of arenes is established via the ruthenium-catalyzed ortho-metalation strategy. This procedure, using Ru3(CO)12 as the catalyst and α-oxocarboxylic acids as the acylation source, featured broad substrate scope, good functional group tolerance, and high regioselectivity. Mechanistic studies demonstrated that a radical process and an 18e-octahedral ruthenium species were involved in this reaction. The present work provides a new strategy for the regioselective meta-acylation reactions and will be a powerful tool for the development of pharmaceutical and materials science.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.8b03695