Loading…

FSO 2 N 3 -Mediated On-DNA Diazo-Transfer Chemistry

DNA-encoded library (DEL) is a powerful hit selection technique in both basic science and innovative drug discovery. In this study, we report a robust and straightforward DNA-compatible diazo-transfer reaction utilizing FSO N as the diazo-transfer reagent in solution. This reaction demonstrates high...

Full description

Saved in:
Bibliographic Details
Published in:ACS medicinal chemistry letters 2024-09, Vol.15 (9), p.1591-1597
Main Authors: Huang, Qianping, Gu, Yuang, Qin, An, Ma, Peixiang, Xu, Hongtao, Zhang, Shuning
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c703-547f3249aa01a681a773984910273c047f12285244125489773dc6295704a9a53
container_end_page 1597
container_issue 9
container_start_page 1591
container_title ACS medicinal chemistry letters
container_volume 15
creator Huang, Qianping
Gu, Yuang
Qin, An
Ma, Peixiang
Xu, Hongtao
Zhang, Shuning
description DNA-encoded library (DEL) is a powerful hit selection technique in both basic science and innovative drug discovery. In this study, we report a robust and straightforward DNA-compatible diazo-transfer reaction utilizing FSO N as the diazo-transfer reagent in solution. This reaction demonstrates high conversions and facile operation while being metal-free and maintaining high levels of DNA fidelity. It is also compatible with a wide range of substrates, allowing for convenient access to both aliphatic and aromatic amines. Consequently, it will further enrich the DEL chemistry toolbox.
doi_str_mv 10.1021/acsmedchemlett.4c00307
format article
fullrecord <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1021_acsmedchemlett_4c00307</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>39291003</sourcerecordid><originalsourceid>FETCH-LOGICAL-c703-547f3249aa01a681a773984910273c047f12285244125489773dc6295704a9a53</originalsourceid><addsrcrecordid>eNpVkM1OwzAQhC0EoqXwCpVfwGX9F8fHKqUFqTQHco8WxxFBTVvZ4VCeHqMWBKddafTt7AwhUw4zDoLfo4u9b9yb77d-GGbKAUgwF2TMrcqZzo2-_LOPyE2M7wCZNQauyUhaYXkixkQuX0oq6IZKyp590-HgG1ru2GIzp4sOP_esCriLrQ-0SGZdHMLxlly1uI3-7jwnpFo-VMUjW5erp2K-Zs6AZFqZVgplEYFjlnM0RtpcJV9hpIOkciFyLZTiQqs8fSYblwmrDSi0qOWEZKezLuxjDL6tD6HrMRxrDvV3CfX_EupzCQmcnsDDx2vSf7Gf1PILH3VXtA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>FSO 2 N 3 -Mediated On-DNA Diazo-Transfer Chemistry</title><source>American Chemical Society:Jisc Collections:American Chemical Society Read &amp; Publish Agreement 2022-2024 (Reading list)</source><creator>Huang, Qianping ; Gu, Yuang ; Qin, An ; Ma, Peixiang ; Xu, Hongtao ; Zhang, Shuning</creator><creatorcontrib>Huang, Qianping ; Gu, Yuang ; Qin, An ; Ma, Peixiang ; Xu, Hongtao ; Zhang, Shuning</creatorcontrib><description>DNA-encoded library (DEL) is a powerful hit selection technique in both basic science and innovative drug discovery. In this study, we report a robust and straightforward DNA-compatible diazo-transfer reaction utilizing FSO N as the diazo-transfer reagent in solution. This reaction demonstrates high conversions and facile operation while being metal-free and maintaining high levels of DNA fidelity. It is also compatible with a wide range of substrates, allowing for convenient access to both aliphatic and aromatic amines. Consequently, it will further enrich the DEL chemistry toolbox.</description><identifier>ISSN: 1948-5875</identifier><identifier>EISSN: 1948-5875</identifier><identifier>DOI: 10.1021/acsmedchemlett.4c00307</identifier><identifier>PMID: 39291003</identifier><language>eng</language><publisher>United States</publisher><ispartof>ACS medicinal chemistry letters, 2024-09, Vol.15 (9), p.1591-1597</ispartof><rights>2024 American Chemical Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c703-547f3249aa01a681a773984910273c047f12285244125489773dc6295704a9a53</cites><orcidid>0000-0002-8785-8848 ; 0000-0001-5174-9079</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39291003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Qianping</creatorcontrib><creatorcontrib>Gu, Yuang</creatorcontrib><creatorcontrib>Qin, An</creatorcontrib><creatorcontrib>Ma, Peixiang</creatorcontrib><creatorcontrib>Xu, Hongtao</creatorcontrib><creatorcontrib>Zhang, Shuning</creatorcontrib><title>FSO 2 N 3 -Mediated On-DNA Diazo-Transfer Chemistry</title><title>ACS medicinal chemistry letters</title><addtitle>ACS Med Chem Lett</addtitle><description>DNA-encoded library (DEL) is a powerful hit selection technique in both basic science and innovative drug discovery. In this study, we report a robust and straightforward DNA-compatible diazo-transfer reaction utilizing FSO N as the diazo-transfer reagent in solution. This reaction demonstrates high conversions and facile operation while being metal-free and maintaining high levels of DNA fidelity. It is also compatible with a wide range of substrates, allowing for convenient access to both aliphatic and aromatic amines. Consequently, it will further enrich the DEL chemistry toolbox.</description><issn>1948-5875</issn><issn>1948-5875</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpVkM1OwzAQhC0EoqXwCpVfwGX9F8fHKqUFqTQHco8WxxFBTVvZ4VCeHqMWBKddafTt7AwhUw4zDoLfo4u9b9yb77d-GGbKAUgwF2TMrcqZzo2-_LOPyE2M7wCZNQauyUhaYXkixkQuX0oq6IZKyp590-HgG1ru2GIzp4sOP_esCriLrQ-0SGZdHMLxlly1uI3-7jwnpFo-VMUjW5erp2K-Zs6AZFqZVgplEYFjlnM0RtpcJV9hpIOkciFyLZTiQqs8fSYblwmrDSi0qOWEZKezLuxjDL6tD6HrMRxrDvV3CfX_EupzCQmcnsDDx2vSf7Gf1PILH3VXtA</recordid><startdate>20240912</startdate><enddate>20240912</enddate><creator>Huang, Qianping</creator><creator>Gu, Yuang</creator><creator>Qin, An</creator><creator>Ma, Peixiang</creator><creator>Xu, Hongtao</creator><creator>Zhang, Shuning</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-8785-8848</orcidid><orcidid>https://orcid.org/0000-0001-5174-9079</orcidid></search><sort><creationdate>20240912</creationdate><title>FSO 2 N 3 -Mediated On-DNA Diazo-Transfer Chemistry</title><author>Huang, Qianping ; Gu, Yuang ; Qin, An ; Ma, Peixiang ; Xu, Hongtao ; Zhang, Shuning</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c703-547f3249aa01a681a773984910273c047f12285244125489773dc6295704a9a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Qianping</creatorcontrib><creatorcontrib>Gu, Yuang</creatorcontrib><creatorcontrib>Qin, An</creatorcontrib><creatorcontrib>Ma, Peixiang</creatorcontrib><creatorcontrib>Xu, Hongtao</creatorcontrib><creatorcontrib>Zhang, Shuning</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><jtitle>ACS medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Qianping</au><au>Gu, Yuang</au><au>Qin, An</au><au>Ma, Peixiang</au><au>Xu, Hongtao</au><au>Zhang, Shuning</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FSO 2 N 3 -Mediated On-DNA Diazo-Transfer Chemistry</atitle><jtitle>ACS medicinal chemistry letters</jtitle><addtitle>ACS Med Chem Lett</addtitle><date>2024-09-12</date><risdate>2024</risdate><volume>15</volume><issue>9</issue><spage>1591</spage><epage>1597</epage><pages>1591-1597</pages><issn>1948-5875</issn><eissn>1948-5875</eissn><abstract>DNA-encoded library (DEL) is a powerful hit selection technique in both basic science and innovative drug discovery. In this study, we report a robust and straightforward DNA-compatible diazo-transfer reaction utilizing FSO N as the diazo-transfer reagent in solution. This reaction demonstrates high conversions and facile operation while being metal-free and maintaining high levels of DNA fidelity. It is also compatible with a wide range of substrates, allowing for convenient access to both aliphatic and aromatic amines. Consequently, it will further enrich the DEL chemistry toolbox.</abstract><cop>United States</cop><pmid>39291003</pmid><doi>10.1021/acsmedchemlett.4c00307</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8785-8848</orcidid><orcidid>https://orcid.org/0000-0001-5174-9079</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 1948-5875
ispartof ACS medicinal chemistry letters, 2024-09, Vol.15 (9), p.1591-1597
issn 1948-5875
1948-5875
language eng
recordid cdi_crossref_primary_10_1021_acsmedchemlett_4c00307
source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
title FSO 2 N 3 -Mediated On-DNA Diazo-Transfer Chemistry
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T02%3A51%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=FSO%202%20N%203%20-Mediated%20On-DNA%20Diazo-Transfer%20Chemistry&rft.jtitle=ACS%20medicinal%20chemistry%20letters&rft.au=Huang,%20Qianping&rft.date=2024-09-12&rft.volume=15&rft.issue=9&rft.spage=1591&rft.epage=1597&rft.pages=1591-1597&rft.issn=1948-5875&rft.eissn=1948-5875&rft_id=info:doi/10.1021/acsmedchemlett.4c00307&rft_dat=%3Cpubmed_cross%3E39291003%3C/pubmed_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c703-547f3249aa01a681a773984910273c047f12285244125489773dc6295704a9a53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/39291003&rfr_iscdi=true