Cocrystal Formation from Solvent Mixtures

Solvent mixtures can be used to thermodynamically suppress solvate formation as a competing reaction in solution-based cocrystallization experiments. This has been demonstrated successfully for the cocrystallization of carbamazepine and saccharin in the presence of up to nine different solvate-formi...

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Bibliographic Details
Published in:Crystal growth & design 2010-07, Vol.10 (7), p.3237-3241
Main Authors: Rager, Timo, Hilfiker, Rolf
Format: Article
Language:English
Subjects:
Condensed matter: structure, mechanical and thermal properties
Cross-disciplinary physics: materials science
rheology
Equations of state, phase equilibria, and phase transitions
Exact sciences and technology
Materials science
Methods of crystal growth
physics of crystal growth
Physics
Solid-solid transitions
Solubility, segregation, and mixing
phase separation
Specific phase transitions
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Summary:Solvent mixtures can be used to thermodynamically suppress solvate formation as a competing reaction in solution-based cocrystallization experiments. This has been demonstrated successfully for the cocrystallization of carbamazepine and saccharin in the presence of up to nine different solvate-forming solvents and was further tested by cocrystallization experiments with 18 other known cocrystal formers of carbamazepine. It was found that the chances of success of this approach increase with the number of solvents in the mixture. It was additionally observed that solvent mixtures can be used to level out the solubility differences between different compounds.
ISSN:1528-7483
1528-7505
DOI:10.1021/cg100361y