Supramolecular Senolytics via Intracellular Oligomerization of Peptides in Response to Elevated Reactive Oxygen Species Levels in Aging Cells

Senolytics, which eliminate senescent cells from tissues, represent an emerging therapeutic strategy for various age-related diseases. Most senolytics target antiapoptotic proteins, which are overexpressed in senescent cells, limiting specificity and inducing severe side effects. To overcome these l...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2023-10, Vol.145 (40), p.21991-22008
Main Authors: Kim, Sangpil, Chae, Jae-Byoung, Kim, Dohyun, Park, Chul-Woo, Sim, Youjung, Lee, Hyungwoo, Park, Gaeun, Lee, Jaeeun, Hong, Seongho, Jana, Batakrishna, Kim, Chaekyu, Chung, Hyewon, Ryu, Ja-Hyoung
Format: Article
Language:English
Subjects:
apoptosis
disulfides
epithelium
fuels
integrins
macular degeneration
mice
mitochondria
mitochondrial membrane
oligomerization
peptides
reactive oxygen species
therapeutics
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