Pd-Catalyzed γ‑C(sp3)–H Arylation of Free Amines Using a Transient Directing Group

Pd­(II)-catalyzed γ-C­(sp3)–H arylation of primary amines is realized by using 2-hydroxy­nicotinaldehyde as a catalytic transient directing group. Importantly, the catalyst and the directing group loading can be lowered to 2% and 4% respectively, thus demonstrating high efficiency of this newly desi...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2016-11, Vol.138 (44), p.14554-14557
Main Authors: Wu, Yongwei, Chen, Yan-Qiao, Liu, Tao, Eastgate, Martin D, Yu, Jin-Quan
Format: Article
Language:English
Subjects:
Alkylation
Amines - chemistry
Catalysis
catalysts
iodides
Molecular Structure
Palladium - chemistry
primary amines
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