Overcoming the Limitations of γ- and δ‑C–H Arylation of Amines through Ligand Development

L,X-Type transient directing groups (TDGs) based on a reversible imine linkage have emerged as broadly useful tools for C–H activation of ketones and free amines. However, competitive binding interactions among multiple reaction components (TDG itself, substrate, and substrate–TDG adduct) with the p...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2018-12, Vol.140 (51), p.17884-17894
Main Authors: Chen, Yan-Qiao, Wang, Zhen, Wu, Yongwei, Wisniewski, Steven R, Qiao, Jennifer X, Ewing, William R, Eastgate, Martin D, Yu, Jin-Quan
Format: Article
Language:English
Subjects:
amines
arylation
carbon-hydrogen bond activation
catalysts
imines
ketones
ligands
organobromine compounds
organoiodine compounds
palladium
pyridones
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