Chemo-enzymatic Total Syntheses of Jorunnamycin A, Saframycin A, and N‑Fmoc Saframycin Y3

The antitumor tetrahydroisoquinoline (THIQ) alkaloids share a common pentacyclic scaffold that is biosynthesized by nonribosomal peptide synthetases involving unique enzymatic Pictet–Spengler cyclizations. Herein we report concise and divergent chemo-enzymatic total syntheses of THIQ alkaloids by me...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2018-08, Vol.140 (34), p.10705-10709
Main Authors: Tanifuji, Ryo, Koketsu, Kento, Takakura, Michiko, Asano, Ryutaro, Minami, Atsushi, Oikawa, Hideaki, Oguri, Hiroki
Format: Article
Language:English
Subjects:
Aldehydes - chemical synthesis
Aldehydes - chemistry
alkaloids
Antibiotics, Antineoplastic - chemical synthesis
biosynthesis
cyclization reactions
Isoquinolines - chemical synthesis
ligases
moieties
Molecular Structure
Peptide Synthases - chemistry
peptides
Protein Engineering - methods
Quinolones - chemical synthesis
Recombinant Proteins - chemistry
synthesis
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