Disposition of Doramectin Milk Residues in Lactating Dairy Sheep

Doramectin (DRM) is a broad spectrum macrocyclic lactone antiparasitic drug not approved for use in dairy animals. However, DRM and other endectocide compounds are widely used extra-label to control endo- and ectoparasites in dairy sheep. The plasma disposition kinetics and the pattern of DRM excret...

Full description

Saved in:
Bibliographic Details
Published in:Journal of agricultural and food chemistry 2003-05, Vol.51 (10), p.3185-3190
Main Authors: Imperiale, Fernanda A, Mottier, Lourdes, Sallovitz, Juan M, Lifschitz, Adrián L, Lanusse, Carlos E
Format: Article
Language:English
Subjects:
Animal productions
Animals
Anthelmintics - administration & dosage
Anthelmintics - analysis
Anthelmintics - pharmacokinetics
Biological and medical sciences
blood flow
Chromatography, High Pressure Liquid
dairy sheep
doramectin
Drug Residues - analysis
ectoparasites
excretion
Female
Food industries
Fundamental and applied biological sciences. Psychology
Ivermectin - administration & dosage
Ivermectin - analogs & derivatives
Ivermectin - analysis
Ivermectin - pharmacokinetics
Lactation
milk
Milk - chemistry
Milk and cheese industries. Ice creams
pharmacokinetics
Sheep
subcutaneous injection
Terrestrial animal productions
Vertebrates
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Doramectin (DRM) is a broad spectrum macrocyclic lactone antiparasitic drug not approved for use in dairy animals. However, DRM and other endectocide compounds are widely used extra-label to control endo- and ectoparasites in dairy sheep. The plasma disposition kinetics and the pattern of DRM excretion in milk were characterized following its subcutaneous administration to lactating dairy sheep. DRM concentration profiles were measured in plasma and milk samples after validation of a specific HPLC-based methodology. DRM was detected between 1 h and 30 days post-treatment. DRM concentrations of 0.48 ng·mL-1 (plasma) and 1.03 ng·mL-1 (milk) were measured at 30 days post-treatment. DRM was extensively distributed from the bloodstream to the mammary gland, and large concentrations were excreted in milk. The peak concentrations and total amount of DRM recovered in milk (expressed as area under the concentration versus time curve) were 3-fold higher than those measured in plasma; 2.44% of the total DRM dose was excreted in milk. The long persistence of DRM milk residues should be seriously considered before its extra-label use in dairy animals is recommended. Keywords: Endectocides; doramectin; milk residues disposition; milk/plasma ratios; dairy sheep
ISSN:0021-8561
1520-5118
DOI:10.1021/jf026118b