Bioprocessing of Wheat Bran Improves in vitro Bioaccessibility and Colonic Metabolism of Phenolic Compounds

Ferulic acid (FA) is the most abundant phenolic compound in wheat grain, mainly located in the bran. However, its bioaccessibility from the bran matrix is extremely low. Different bioprocessing techniques involving fermentation or enzymatic and fermentation treatments of wheat bran were developed ai...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2009-07, Vol.57 (14), p.6148-6155
Main Authors: Anson, Nuria Mateo, Selinheimo, Emilia, Havenaar, Rob, Aura, Anna-Marja, Mattila, Ismo, Lehtinen, Pekka, Bast, Aalt, Poutanen, Kaisa, Haenen, Guido R. M. M
Format: Article
Language:English
Subjects:
Adult
Bioactive Constituents
Biological and medical sciences
Biological Availability
Cereal and baking product industries
Colon - metabolism
Colon - microbiology
Coumaric Acids - pharmacokinetics
Dietary Fiber - analysis
Dietary Fiber - metabolism
Digestion
Female
Fermentation
Food Handling - methods
Food industries
Fundamental and applied biological sciences. Psychology
Gastrointestinal Tract - metabolism
Humans
Hydrolases - metabolism
In Vitro Techniques
Male
Models, Biological
Phenols - metabolism
Phenols - pharmacokinetics
Phenylpropionates - metabolism
Propionates
Saccharomyces cerevisiae - metabolism
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Summary:Ferulic acid (FA) is the most abundant phenolic compound in wheat grain, mainly located in the bran. However, its bioaccessibility from the bran matrix is extremely low. Different bioprocessing techniques involving fermentation or enzymatic and fermentation treatments of wheat bran were developed aiming at improving the bioaccessibility of phenolic compounds in bran-containing breads. The bioaccessibility of ferulic acid, p-coumaric acid, and sinapic acid was assessed with an in vitro model of upper gastrointestinal tract (TIM-1). Colonic metabolism of the phenolic compounds in the nonbioaccessible fraction of the breads was studied with an in vitro model of human colon (TIM-2). The most effective treatment was the combination of enzymes and fermentation that increased the bioaccessibility of FA from 1.1% to 5.5%. The major colonic metabolites were 3-(3-hydroxyphenyl)propionic acid and 3-phenylpropionic acid. Bran bioprocessing increases the bioaccessibility of phenolic compounds as well as the colonic end metabolite 3-phenylpropionic acid.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf900492h