Mammalian Drug Metabolism

Drugs and other chemicals that do not occur in mammalian systems are metabolized by a wide variety of enzymes. Reactions catalyzed by these enzymes have been classified into two general phases. Phase I reactions include oxidations, reductions, and hydrolyses, whereas Phase II reactions are broadly d...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1983-01, Vol.46 (1), p.71-78
Main Authors: Nelson, Sidney D, Gordon, W. Perry
Format: Article
Language:English
Subjects:
Abortifacient Agents - metabolism
Acetaminophen - metabolism
Acylation
Animals
Biological and medical sciences
Cyclohexanones - metabolism
General pharmacology
Humans
Hydrolysis
Inactivation, Metabolic
Mammals - metabolism
Medical sciences
Methylation
Mice
Mice, Inbred BALB C
Oils, Volatile - metabolism
Oxidation-Reduction
Pharmaceutical Preparations - metabolism
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Terpenes - metabolism
Terpenes - toxicity
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Drugs and other chemicals that do not occur in mammalian systems are metabolized by a wide variety of enzymes. Reactions catalyzed by these enzymes have been classified into two general phases. Phase I reactions include oxidations, reductions, and hydrolyses, whereas Phase II reactions are broadly defined as conjugation reactions and include glucuronidation, sulfation, acylation, methylation, and conjugation with glutathione. The mechanisms of these biotransformations are outlined to demonstrate how both non-toxic and toxic metabolites are produced. The mammalian metabolism of acetaminophen, a widely used mild analgesic, and R-(+)-pulegone, the major constituent terpene of pennyroyal oil, will be discussed to illustrate specific features of mammalian drug metabolism.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50025a005