Inability of Plasma from Patients with Neoplasia to support Macrophage Recognition of Foreignness

THE involvement of the reticuloendothelial system (RES) in various disease processes is well documented, but the role of phagocytic promoting factors, or opsonins 1–4 , is still not clear. Opsonic depletion in animals—the so-called “blockade” 5–8 —has been shown to be associated with decreased immun...

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Bibliographic Details
Published in:Nature (London) 1970-06, Vol.226 (5250), p.1049-1050
Main Authors: PISANO, J. C, DI LUZIO, N. R, SALKY, N. K
Format: Article
Language:English
Subjects:
Humanities and Social Sciences
letter
multidisciplinary
Science
Science (multidisciplinary)
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Summary:THE involvement of the reticuloendothelial system (RES) in various disease processes is well documented, but the role of phagocytic promoting factors, or opsonins 1–4 , is still not clear. Opsonic depletion in animals—the so-called “blockade” 5–8 —has been shown to be associated with decreased immunogenicity 9–11 and impaired resistance to infection 12,13 . Because tumour cells which possess tumour-specific antigens 14 are, effectively, “non-self” it is possible that serum opsonic depletion might occur in the neoplastic patient. Phagocytic alterations have been found in patients with neoplasia 15–18 , but it is not known if these are attributable to a macrophage alteration or an opsonic defect.
ISSN:0028-0836
1476-4687
DOI:10.1038/2261049a0