Heterotransplantation of Cultured Cell Lines in Newborn Hamsters treated with Antilymphocyte Serum

CELL lines derived from neoplastic tissue differ from those from normal adult tissue 1 in their capacity to survive and grow in the cheek pouch of a hamster treated with cortisone, and this difference is now the basis of a test for potential malignancy. We have found a simple and rapid alternative i...

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Bibliographic Details
Published in:Nature (London) 1971-04, Vol.230 (5294), p.454-455
Main Authors: WALLACE, ROSLYN, VASINGTON, PAUL J, PETRICCIANI, JOHN C
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Antilymphocyte Serum
Carcinoma
Cell Count
Cell Line
Cricetinae
Cytotoxicity Tests, Immunologic
Haplorhini
Humanities and Social Sciences
Humans
Kidney
letter
Lung
Mouth Neoplasms
multidisciplinary
Neoplasm Metastasis
Neoplasm Transplantation
Rabbits
Science
Science (multidisciplinary)
Transplantation Immunology
Transplantation, Heterologous
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Summary:CELL lines derived from neoplastic tissue differ from those from normal adult tissue 1 in their capacity to survive and grow in the cheek pouch of a hamster treated with cortisone, and this difference is now the basis of a test for potential malignancy. We have found a simple and rapid alternative in the use of hamsters treated with antilymphocyte serum (ALS) and this may be valuable in the screening for tumorigenicity in human diploid cell strains used in the production of virus vaccines 2,3 . ALS is an effective suppressor of immune responses to skin allografts 4 , of tumour induction by oncogenic viruses 5 and of the development of metastases of allogeneic tumour grafts 6 . It is also known that tumours are formed in ALS-treated weanling mice after subcutaneous inoculation of cultured human tumour cells 7,8 . It was this that suggested that ALS may provide an improved alternative to standard methods of host conditioning for tumour transplantation.
ISSN:0028-0836
1476-4687
DOI:10.1038/230454a0