Marked prolongation of post-tetanic potentiation at a transition temperature and its adaptation

A UNITARY, monosynaptic excitatory postsynaptic potential (e.p.s.p.) can be recorded from cell R15 of the abdominal ganglion of Aplysia californica on appropriate stimulation of the right visceropleural connective. The amplitude of this e.p.s.p. undergoes a sequence of changes with trains of one or...

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Bibliographic Details
Published in:Nature (London) 1975-12, Vol.258 (5536), p.623-625
Main Authors: SCHLAPFER, WERNER T, WOODSON, PAUL B. J, SMITH, GARY A, TREMBLAY, JACQUES P, BARONDES, SAMUEL H
Format: Article
Language:English
Subjects:
Humanities and Social Sciences
letter
multidisciplinary
Science
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Summary:A UNITARY, monosynaptic excitatory postsynaptic potential (e.p.s.p.) can be recorded from cell R15 of the abdominal ganglion of Aplysia californica on appropriate stimulation of the right visceropleural connective. The amplitude of this e.p.s.p. undergoes a sequence of changes with trains of one or two stimuli per second. These changes include synaptic depression, frequency facilitation and post-tetanic potentiation. As described in detail elsewhere 1,2 , all these phenomena are apparently due to alterations in the amount of neurotransmitter released rather than to postsynaptic mechanisms. The frequency facilitation, a relatively transient phenomenon, is believed to be limited by the rate of neurotransmitter mobilisation into the pool available for release 2 . In contrast, the post-tetanic potentiation, a much more sustained phenomenon, is believed to be due to a change in the fraction of the available pool of transmitter released per stimulus 2 .
ISSN:0028-0836
1476-4687
DOI:10.1038/258623a0