Clinical utility of recently identified diagnostic, prognostic, and predictive molecular biomarkers in mature B-cell neoplasms

Genomic profiling studies have provided new insights into the pathogenesis of mature B-cell neoplasms and have identified markers with prognostic impact. Recurrent mutations in tumor-suppressor genes ( TP53, BIRC3, ATM ), and common signaling pathways, such as the B-cell receptor ( CD79A , CD79B , C...

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Bibliographic Details
Published in:Modern pathology 2017-10, Vol.30 (10), p.1338-1366
Main Authors: Onaindia, Arantza, Medeiros, L Jeffrey, Patel, Keyur P
Format: Article
Language:English
Subjects:
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B-cell lymphoma
B-cell receptor
Biomarkers
Biomarkers, Tumor - analysis
Burkitt's lymphoma
Chronic lymphocytic leukemia
Hairy cell leukemia
Humans
Laboratory Medicine
Leukemia
Leukemia, B-Cell - diagnosis
Leukemia, B-Cell - genetics
Leukemia, B-Cell - mortality
Lymphatic leukemia
Lymphocytes B
Lymphoma
Lymphoma, B-Cell - diagnosis
Lymphoma, B-Cell - genetics
Lymphoma, B-Cell - mortality
Macroglobulinemia
Mantle cell lymphoma
Medical diagnosis
Medical prognosis
Medicine
Medicine & Public Health
MyD88 protein
Notch1 protein
p53 Protein
Pathology
review-article
Spleen
Toll-like receptors
Tumor suppressor genes
Tumors
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