Structure of the intact ATM/Tel1 kinase

The ataxia-telangiectasia mutated (ATM) protein is an apical kinase that orchestrates the multifaceted DNA-damage response. Normally, ATM kinase is in an inactive, homodimer form and is transformed into monomers upon activation. Besides a conserved kinase domain at the C terminus, ATM contains three...

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Bibliographic Details
Published in:Nature communications 2016-05, Vol.7 (1), p.11655-8, Article 11655
Main Authors: Wang, Xuejuan, Chu, Huanyu, Lv, Mengjuan, Zhang, Zhihui, Qiu, Shuwan, Liu, Haiyan, Shen, Xuetong, Wang, Weiwu, Cai, Gang
Format: Article
Language:English
Subjects:
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Amino Acid Sequence
Ataxia
Ataxia Telangiectasia Mutated Proteins - chemistry
Ataxia Telangiectasia Mutated Proteins - genetics
Ataxia Telangiectasia Mutated Proteins - metabolism
Binding Sites - genetics
Cancer
Cryoelectron Microscopy
Crystal structure
DNA repair
Genomes
Humanities and Social Sciences
Kinases
Life sciences
Models, Molecular
multidisciplinary
Protein Conformation
Protein Multimerization
Protein-Serine-Threonine Kinases - chemistry
Protein-Serine-Threonine Kinases - genetics
Protein-Serine-Threonine Kinases - metabolism
Proteins
Schizosaccharomyces - genetics
Schizosaccharomyces - metabolism
Schizosaccharomyces pombe Proteins - chemistry
Schizosaccharomyces pombe Proteins - genetics
Schizosaccharomyces pombe Proteins - metabolism
Science
Science (multidisciplinary)
Sequence Homology, Amino Acid
Yeast
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