Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble

Type III-A CRISPR-Cas systems are prokaryotic RNA-guided adaptive immune systems that use a protein-RNA complex, Csm, for transcription-dependent immunity against foreign DNA. Csm can cleave RNA and single-stranded DNA (ssDNA), but whether it targets one or both nucleic acids during transcription el...

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Bibliographic Details
Published in:Nature communications 2019-07, Vol.10 (1), p.3001-13, Article 3001
Main Authors: Liu, Tina Y., Liu, Jun-Jie, Aditham, Abhishek J., Nogales, Eva, Doudna, Jennifer A.
Format: Article
Language:English
Subjects:
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Adaptive Immunity - genetics
Adaptive systems
Bacteriophages - immunology
BASIC BIOLOGICAL SCIENCES
Clustered Regularly Interspaced Short Palindromic Repeats - genetics
Clustered Regularly Interspaced Short Palindromic Repeats - immunology
CRISPR
CRISPR-Cas Systems - genetics
CRISPR-Cas Systems - immunology
Deoxyribonucleic acid
DNA
DNA, Single-Stranded - genetics
DNA, Single-Stranded - immunology
DNA, Single-Stranded - metabolism
DNA-directed RNA polymerase
DNA-Directed RNA Polymerases - metabolism
Elongation
Gene silencing
Humanities and Social Sciences
Immune system
Immunity
multidisciplinary
Nucleic acids
Phages
Plasmids
Plasmids - immunology
Ribonucleic acid
RNA
RNA polymerase
RNA, Guide, CRISPR-Cas Systems - genetics
RNA, Guide, CRISPR-Cas Systems - immunology
RNA, Guide, CRISPR-Cas Systems - metabolism
RNA-mediated interference
Science
Science (multidisciplinary)
Single-stranded DNA
Staphylococcus epidermidis
Staphylococcus epidermidis - genetics
Staphylococcus epidermidis - immunology
Tethering
Thermus thermophilus - genetics
Thermus thermophilus - immunology
Transcription elongation
Transcription Elongation, Genetic - immunology
Yeast
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