Cryo-EM structure of a 40 kDa SAM-IV riboswitch RNA at 3.7 Å resolution

Specimens below 50 kDa have generally been considered too small to be analyzed by single-particle cryo-electron microscopy (cryo-EM). The high flexibility of pure RNAs makes it difficult to obtain high-resolution structures by cryo-EM. In bacteria, riboswitches regulate sulfur metabolism through bin...

Full description

Saved in:
Bibliographic Details
Published in:Nature communications 2019-12, Vol.10 (1), p.5511-6, Article 5511
Main Authors: Zhang, Kaiming, Li, Shanshan, Kappel, Kalli, Pintilie, Grigore, Su, Zhaoming, Mou, Tung-Chung, Schmid, Michael F., Das, Rhiju, Chiu, Wah
Format: Article
Language:English
Subjects:
101/28
631/45/500
631/535/1258/1259
Adenosylmethionine
Antibiotics
BASIC BIOLOGICAL SCIENCES
Binding
Cryoelectron Microscopy
Drug development
Electron microscopy
Homology
Humanities and Social Sciences
Ligands
Molecular Weight
multidisciplinary
Nucleic Acid Conformation
Ribonucleic acid
Riboswitch
Riboswitches
RNA
S-Adenosylmethionine
S-Adenosylmethionine - chemistry
Science
Science (multidisciplinary)
Sulfur
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!