TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation

The transcription factor MYC is deregulated in almost all human cancers, especially in aggressive lymphomas, through chromosomal translocation, amplification, and transcription hyperactivation. Here, we report that high expression of tribbles homologue 3 (TRIB3) positively correlates with elevated M...

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Bibliographic Details
Published in:	Nature communications 2020-12, Vol.11 (1), p.6316-20, Article 6316
Main Authors:	Li, Ke, Wang, Feng, Yang, Zhao-na, Zhang, Ting-ting, Yuan, Yu-fen, Zhao, Chen-xi, Yeerjiang, Zaiwuli, Cui, Bing, Hua, Fang, Lv, Xiao-xi, Zhang, Xiao-wei, Yu, Jiao-jiao, Liu, Shan-shan, Yu, Jin-mei, Shang, Shuang, Xiao, Yang, Hu, Zhuo-wei
Format:	Article
Language:	English
Subjects:	13 13/1 13/109 13/2 13/31 13/51 13/89 14 38 38/91 49 49/15 49/22 631/80/458/582 64/60 692/4028/67/1990/291/1621 82/80 82/83 96 Adolescent Adult Aged Aged, 80 and over Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use c-Myc protein Cancer Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor Cell proliferation Cell Self Renewal - drug effects Cell Self Renewal - genetics Chromatin Immunoprecipitation Sequencing Degradation Deregulation Disease Progression Doxorubicin Female Gene Expression Regulation, Neoplastic Gene Knock-In Techniques Gene Knockdown Techniques HEK293 Cells Homology Humanities and Social Sciences Humans Lymphoma Lymphoma, Non-Hodgkin - drug therapy Lymphoma, Non-Hodgkin - genetics Lymphoma, Non-Hodgkin - pathology Male Mice Mice, Knockout Middle Aged multidisciplinary Myc protein Primary Cell Culture Proteasome Endopeptidase Complex - metabolism Proteasome Inhibitors - pharmacology Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteolysis - drug effects Proto-Oncogene Proteins c-myc - antagonists & inhibitors Proto-Oncogene Proteins c-myc - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism RNA-Seq Science Science (multidisciplinary) Translocation Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - metabolism Ubiquitination Ubiquitination - drug effects Ubiquitination - genetics Xenograft Model Antitumor Assays Xenografts Xenotransplantation Young Adult
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