Accurate structure prediction of biomolecular interactions with AlphaFold 3

The introduction of AlphaFold 2 1 has spurred a revolution in modelling the structure of proteins and their interactions, enabling a huge range of applications in protein modelling and design 2 , 3 , 4 , 5 – 6 . Here we describe our AlphaFold 3 model with a substantially updated diffusion-based arch...

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Published in:	Nature (London) 2024-06, Vol.630 (8016), p.493-500
Main Authors:	Abramson, Josh, Adler, Jonas, Dunger, Jack, Evans, Richard, Green, Tim, Pritzel, Alexander, Ronneberger, Olaf, Willmore, Lindsay, Ballard, Andrew J., Bambrick, Joshua, Bodenstein, Sebastian W., Evans, David A., Hung, Chia-Chun, O’Neill, Michael, Reiman, David, Tunyasuvunakool, Kathryn, Wu, Zachary, Žemgulytė, Akvilė, Arvaniti, Eirini, Beattie, Charles, Bertolli, Ottavia, Bridgland, Alex, Cherepanov, Alexey, Congreve, Miles, Cowen-Rivers, Alexander I., Cowie, Andrew, Figurnov, Michael, Fuchs, Fabian B., Gladman, Hannah, Jain, Rishub, Khan, Yousuf A., Low, Caroline M. R., Perlin, Kuba, Potapenko, Anna, Savy, Pascal, Singh, Sukhdeep, Stecula, Adrian, Thillaisundaram, Ashok, Tong, Catherine, Yakneen, Sergei, Zhong, Ellen D., Zielinski, Michal, Žídek, Augustin, Bapst, Victor, Kohli, Pushmeet, Jaderberg, Max, Hassabis, Demis, Jumper, John M.
Format:	Article
Language:	English
Subjects:	631/114/1305 631/114/2411 631/154 631/535 Accuracy Antibodies - chemistry Antibodies - metabolism Antigens - chemistry Antigens - metabolism Deep Learning - standards Humanities and Social Sciences Humans Ions - chemistry Ions - metabolism Ligands Modelling Models, Molecular Molecular Docking Simulation multidisciplinary Nucleic acids Nucleic Acids - chemistry Nucleic Acids - metabolism Protein Binding Protein Conformation Proteins Proteins - chemistry Proteins - metabolism Reproducibility of Results Science Science (multidisciplinary) Software - standards
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