RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently needed. We developed a robust and simple, PCR-based host-blood transcriptomic signature, RISK6, for multiple applications: identifying individuals at risk of incident disease, as a screening test for subclinic...

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Published in:	Scientific reports 2020-05, Vol.10 (1), p.8629, Article 8629
Main Authors:	Penn-Nicholson, Adam, Mbandi, Stanley Kimbung, Thompson, Ethan, Mendelsohn, Simon C., Suliman, Sara, Chegou, Novel N., Malherbe, Stephanus T., Darboe, Fatoumatta, Erasmus, Mzwandile, Hanekom, Willem A., Bilek, Nicole, Fisher, Michelle, Kaufmann, Stefan H. E., Winter, Jill, Murphy, Melissa, Wood, Robin, Morrow, Carl, Van Rhijn, Ildiko, Moody, Branch, Murray, Megan, Andrade, Bruno B., Sterling, Timothy R., Sutherland, Jayne, Naidoo, Kogieleum, Padayatchi, Nesri, Walzl, Gerhard, Hatherill, Mark, Zak, Daniel, Scriba, Thomas J.
Format:	Article
Language:	English
Subjects:	38/91 692/53/2421 692/53/2422 692/699/255/1856 Adolescent Area Under Curve Benchmarks Biomarkers - metabolism Blood Capillary tubes Cohort Studies Emission measurements Female Health risks HIV HIV Infections - complications HIV Infections - pathology Human immunodeficiency virus Humanities and Social Sciences Humans Lung - diagnostic imaging Lung - innervation Lung - pathology Male multidisciplinary Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Point-of-Care Systems Positron emission tomography Prognosis Real-Time Polymerase Chain Reaction - methods RNA, Bacterial - metabolism ROC Curve Science Science (multidisciplinary) Sensitivity analysis Sensitivity and Specificity Sputum Tuberculosis Tuberculosis - complications Tuberculosis - diagnosis Tuberculosis - microbiology
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