Greener [3+3] tandem annulation–oxidation approach towards the synthesis of substituted pyrimidines

An economical and green synthesis of partly and fully substituted pyrimidines is described using α,β-unsaturated ketones and benzamidine hydrochloride using greener and recyclable choline hydroxide (ChOH) as both a catalyst and a reaction medium. The remarkable features of this method are mild react...

Full description

Saved in:
Bibliographic Details
Published in:New journal of chemistry 2015-01, Vol.39 (5), p.3639-3645
Main Authors: Vadagaonkar, Kamlesh S., Kalmode, Hanuman P., Prakash, Sattey, Chaskar, Atul C.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c231t-4663537f3d90c6a61dd38a541619deae2f14a4416a46bd07826021465dc0fa23
cites cdi_FETCH-LOGICAL-c231t-4663537f3d90c6a61dd38a541619deae2f14a4416a46bd07826021465dc0fa23
container_end_page 3645
container_issue 5
container_start_page 3639
container_title New journal of chemistry
container_volume 39
creator Vadagaonkar, Kamlesh S.
Kalmode, Hanuman P.
Prakash, Sattey
Chaskar, Atul C.
description An economical and green synthesis of partly and fully substituted pyrimidines is described using α,β-unsaturated ketones and benzamidine hydrochloride using greener and recyclable choline hydroxide (ChOH) as both a catalyst and a reaction medium. The remarkable features of this method are mild reaction conditions, short reaction times, easy workup procedure, recyclability of the catalyst and excellent yields of the products. The reaction involves a [3+3] annulation–oxidation sequence and the protocol is useful for synthesizing a broad range of biologically significant pyrimidine derivatives.
doi_str_mv 10.1039/C4NJ02345E
format article
fullrecord <record><control><sourceid>crossref</sourceid><recordid>TN_cdi_crossref_primary_10_1039_C4NJ02345E</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1039_C4NJ02345E</sourcerecordid><originalsourceid>FETCH-LOGICAL-c231t-4663537f3d90c6a61dd38a541619deae2f14a4416a46bd07826021465dc0fa23</originalsourceid><addsrcrecordid>eNpFkE1OwzAUhC0EEqWw4QRegwJ-tuM0SxSVAqpg0x1C0Wtsq0atE9mOIDvu0BtyEsKPxGq-2YxGHyHnwK6AifK6ko8PjAuZzw_IBIQqs5IrOBwZpMxYLtUxOYnxlTGAQsGEmEUwxptAn8WleKEJvTY7it73W0yu9Z8f-_bd6R-m2HWhxWZDU_uGQUeaNobGwY8RXaStpbFfx-RSn4ym3RDczmnnTTwlRxa30Zz95ZSsbuer6i5bPi3uq5tl1nABKZNKiVwUVuiSNQoVaC1mmEtQUGqDhluQKMeKUq01K2ZcMQ5S5bphFrmYkovf2Sa0MQZj6268gGGogdXffup_P-ILoaZaXQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Greener [3+3] tandem annulation–oxidation approach towards the synthesis of substituted pyrimidines</title><source>Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list)</source><creator>Vadagaonkar, Kamlesh S. ; Kalmode, Hanuman P. ; Prakash, Sattey ; Chaskar, Atul C.</creator><creatorcontrib>Vadagaonkar, Kamlesh S. ; Kalmode, Hanuman P. ; Prakash, Sattey ; Chaskar, Atul C.</creatorcontrib><description>An economical and green synthesis of partly and fully substituted pyrimidines is described using α,β-unsaturated ketones and benzamidine hydrochloride using greener and recyclable choline hydroxide (ChOH) as both a catalyst and a reaction medium. The remarkable features of this method are mild reaction conditions, short reaction times, easy workup procedure, recyclability of the catalyst and excellent yields of the products. The reaction involves a [3+3] annulation–oxidation sequence and the protocol is useful for synthesizing a broad range of biologically significant pyrimidine derivatives.</description><identifier>ISSN: 1144-0546</identifier><identifier>EISSN: 1369-9261</identifier><identifier>DOI: 10.1039/C4NJ02345E</identifier><language>eng</language><ispartof>New journal of chemistry, 2015-01, Vol.39 (5), p.3639-3645</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c231t-4663537f3d90c6a61dd38a541619deae2f14a4416a46bd07826021465dc0fa23</citedby><cites>FETCH-LOGICAL-c231t-4663537f3d90c6a61dd38a541619deae2f14a4416a46bd07826021465dc0fa23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Vadagaonkar, Kamlesh S.</creatorcontrib><creatorcontrib>Kalmode, Hanuman P.</creatorcontrib><creatorcontrib>Prakash, Sattey</creatorcontrib><creatorcontrib>Chaskar, Atul C.</creatorcontrib><title>Greener [3+3] tandem annulation–oxidation approach towards the synthesis of substituted pyrimidines</title><title>New journal of chemistry</title><description>An economical and green synthesis of partly and fully substituted pyrimidines is described using α,β-unsaturated ketones and benzamidine hydrochloride using greener and recyclable choline hydroxide (ChOH) as both a catalyst and a reaction medium. The remarkable features of this method are mild reaction conditions, short reaction times, easy workup procedure, recyclability of the catalyst and excellent yields of the products. The reaction involves a [3+3] annulation–oxidation sequence and the protocol is useful for synthesizing a broad range of biologically significant pyrimidine derivatives.</description><issn>1144-0546</issn><issn>1369-9261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNpFkE1OwzAUhC0EEqWw4QRegwJ-tuM0SxSVAqpg0x1C0Wtsq0atE9mOIDvu0BtyEsKPxGq-2YxGHyHnwK6AifK6ko8PjAuZzw_IBIQqs5IrOBwZpMxYLtUxOYnxlTGAQsGEmEUwxptAn8WleKEJvTY7it73W0yu9Z8f-_bd6R-m2HWhxWZDU_uGQUeaNobGwY8RXaStpbFfx-RSn4ym3RDczmnnTTwlRxa30Zz95ZSsbuer6i5bPi3uq5tl1nABKZNKiVwUVuiSNQoVaC1mmEtQUGqDhluQKMeKUq01K2ZcMQ5S5bphFrmYkovf2Sa0MQZj6268gGGogdXffup_P-ILoaZaXQ</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Vadagaonkar, Kamlesh S.</creator><creator>Kalmode, Hanuman P.</creator><creator>Prakash, Sattey</creator><creator>Chaskar, Atul C.</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20150101</creationdate><title>Greener [3+3] tandem annulation–oxidation approach towards the synthesis of substituted pyrimidines</title><author>Vadagaonkar, Kamlesh S. ; Kalmode, Hanuman P. ; Prakash, Sattey ; Chaskar, Atul C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c231t-4663537f3d90c6a61dd38a541619deae2f14a4416a46bd07826021465dc0fa23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vadagaonkar, Kamlesh S.</creatorcontrib><creatorcontrib>Kalmode, Hanuman P.</creatorcontrib><creatorcontrib>Prakash, Sattey</creatorcontrib><creatorcontrib>Chaskar, Atul C.</creatorcontrib><collection>CrossRef</collection><jtitle>New journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vadagaonkar, Kamlesh S.</au><au>Kalmode, Hanuman P.</au><au>Prakash, Sattey</au><au>Chaskar, Atul C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Greener [3+3] tandem annulation–oxidation approach towards the synthesis of substituted pyrimidines</atitle><jtitle>New journal of chemistry</jtitle><date>2015-01-01</date><risdate>2015</risdate><volume>39</volume><issue>5</issue><spage>3639</spage><epage>3645</epage><pages>3639-3645</pages><issn>1144-0546</issn><eissn>1369-9261</eissn><abstract>An economical and green synthesis of partly and fully substituted pyrimidines is described using α,β-unsaturated ketones and benzamidine hydrochloride using greener and recyclable choline hydroxide (ChOH) as both a catalyst and a reaction medium. The remarkable features of this method are mild reaction conditions, short reaction times, easy workup procedure, recyclability of the catalyst and excellent yields of the products. The reaction involves a [3+3] annulation–oxidation sequence and the protocol is useful for synthesizing a broad range of biologically significant pyrimidine derivatives.</abstract><doi>10.1039/C4NJ02345E</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1144-0546
ispartof New journal of chemistry, 2015-01, Vol.39 (5), p.3639-3645
issn 1144-0546
1369-9261
language eng
recordid cdi_crossref_primary_10_1039_C4NJ02345E
source Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list)
title Greener [3+3] tandem annulation–oxidation approach towards the synthesis of substituted pyrimidines
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T18%3A02%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-crossref&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Greener%20%5B3+3%5D%20tandem%20annulation%E2%80%93oxidation%20approach%20towards%20the%20synthesis%20of%20substituted%20pyrimidines&rft.jtitle=New%20journal%20of%20chemistry&rft.au=Vadagaonkar,%20Kamlesh%20S.&rft.date=2015-01-01&rft.volume=39&rft.issue=5&rft.spage=3639&rft.epage=3645&rft.pages=3639-3645&rft.issn=1144-0546&rft.eissn=1369-9261&rft_id=info:doi/10.1039/C4NJ02345E&rft_dat=%3Ccrossref%3E10_1039_C4NJ02345E%3C/crossref%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c231t-4663537f3d90c6a61dd38a541619deae2f14a4416a46bd07826021465dc0fa23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true