An efficient approach to 1,2,3-trisubstituted indole via rhodium catalyzed carbene C sp3 –H bond insertion

A method for convenient synthesis of N -alkyl-2-aryl-indole-3-carbaldehyde has been described. A variety of highly valuable indolyl aldehydes have been prepared through this method. Electron donating groups on both aromatic rings (anilinyl and benzyl) facilitate the formation of the desired products...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2015, Vol.13 (17), p.4851-4854
Main Authors: Shen, Mei-Hua, Pan, Ying-Peng, Jia, Zhi-Hong, Ren, Xin-Tao, Zhang, Ping, Xu, Hua-Dong
Format: Article
Language:English
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Summary:A method for convenient synthesis of N -alkyl-2-aryl-indole-3-carbaldehyde has been described. A variety of highly valuable indolyl aldehydes have been prepared through this method. Electron donating groups on both aromatic rings (anilinyl and benzyl) facilitate the formation of the desired products. A benzylic C–H insertion by rhodium carbene is the key step for this transformation.
ISSN:1477-0520
1477-0539
DOI:10.1039/C5OB00085H