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Transition-metal-free solid phase synthesis of 1,2-disubstituted 4-quinolones via the regiospecific synthesis of enaminones
Herein, the transition-metal-free economical solid phase synthesis of 1,2-disubstituted 4-quinolones has been developed via the novel regiospecific synthesis of enaminones. Notably, a wide range of enaminones were synthesized via a silica-supported solid-phase reaction in good to excellent yields. T...
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| Published in: | RSC advances 2016, Vol.6 (14), p.11528-11535 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c297t-1b0f3a847fb37e354bc304f6fef3331d5c8380e98d584372a8cb4b7e326fe7cc3 |
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| cites | cdi_FETCH-LOGICAL-c297t-1b0f3a847fb37e354bc304f6fef3331d5c8380e98d584372a8cb4b7e326fe7cc3 |
| container_end_page | 11535 |
| container_issue | 14 |
| container_start_page | 11528 |
| container_title | RSC advances |
| container_volume | 6 |
| creator | Vinayaka, Ajjampura C. Swaroop, Toreshettahally R. Chikkade, Prasanna Kumara Rangappa, Kanchugarakoppal S. Sadashiva, Maralinganadoddi P. |
| description | Herein, the transition-metal-free economical solid phase synthesis of 1,2-disubstituted 4-quinolones has been developed
via
the novel regiospecific synthesis of enaminones. Notably, a wide range of enaminones were synthesized
via
a silica-supported solid-phase reaction in good to excellent yields. The transformation of enaminones to 1,2-disubstituted 4-quinolones and
N
-methyl-2-aryl-4-quinolone alkaloid was achieved in high yield
via
an alumina-supported solid phase reaction. In addition, all the synthesized compounds were isolated directly in their pure form from the reaction mixture using an easy workup procedure. |
| doi_str_mv | 10.1039/C5RA21421A |
| format | article |
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via
the novel regiospecific synthesis of enaminones. Notably, a wide range of enaminones were synthesized
via
a silica-supported solid-phase reaction in good to excellent yields. The transformation of enaminones to 1,2-disubstituted 4-quinolones and
N
-methyl-2-aryl-4-quinolone alkaloid was achieved in high yield
via
an alumina-supported solid phase reaction. In addition, all the synthesized compounds were isolated directly in their pure form from the reaction mixture using an easy workup procedure.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/C5RA21421A</identifier><language>eng</language><ispartof>RSC advances, 2016, Vol.6 (14), p.11528-11535</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c297t-1b0f3a847fb37e354bc304f6fef3331d5c8380e98d584372a8cb4b7e326fe7cc3</citedby><cites>FETCH-LOGICAL-c297t-1b0f3a847fb37e354bc304f6fef3331d5c8380e98d584372a8cb4b7e326fe7cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids></links><search><creatorcontrib>Vinayaka, Ajjampura C.</creatorcontrib><creatorcontrib>Swaroop, Toreshettahally R.</creatorcontrib><creatorcontrib>Chikkade, Prasanna Kumara</creatorcontrib><creatorcontrib>Rangappa, Kanchugarakoppal S.</creatorcontrib><creatorcontrib>Sadashiva, Maralinganadoddi P.</creatorcontrib><title>Transition-metal-free solid phase synthesis of 1,2-disubstituted 4-quinolones via the regiospecific synthesis of enaminones</title><title>RSC advances</title><description>Herein, the transition-metal-free economical solid phase synthesis of 1,2-disubstituted 4-quinolones has been developed
via
the novel regiospecific synthesis of enaminones. Notably, a wide range of enaminones were synthesized
via
a silica-supported solid-phase reaction in good to excellent yields. The transformation of enaminones to 1,2-disubstituted 4-quinolones and
N
-methyl-2-aryl-4-quinolone alkaloid was achieved in high yield
via
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via
the novel regiospecific synthesis of enaminones. Notably, a wide range of enaminones were synthesized
via
a silica-supported solid-phase reaction in good to excellent yields. The transformation of enaminones to 1,2-disubstituted 4-quinolones and
N
-methyl-2-aryl-4-quinolone alkaloid was achieved in high yield
via
an alumina-supported solid phase reaction. In addition, all the synthesized compounds were isolated directly in their pure form from the reaction mixture using an easy workup procedure.</abstract><doi>10.1039/C5RA21421A</doi><tpages>8</tpages></addata></record> |
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| ispartof | RSC advances, 2016, Vol.6 (14), p.11528-11535 |
| issn | 2046-2069 2046-2069 |
| language | eng |
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| source | Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list) |
| title | Transition-metal-free solid phase synthesis of 1,2-disubstituted 4-quinolones via the regiospecific synthesis of enaminones |
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