Mechanochemical functionalization of disulfide linked hydrogels

Poly(ethylene glycol) hydrogels with disulfide linkages are functionalized through applied force. Compression or tension induces bond rupture at the relatively weak disulfide linkages, which will subsequently react through Michael-type addition with an acceptor molecule within the gel. We demonstrat...

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Bibliographic Details
Published in:Materials horizons 2016-01, Vol.3 (5), p.447-451
Main Authors: Lee, Junmin, Silberstein, Meredith N, Abdeen, Amr A, Kim, Sang Yup, Kilian, Kristopher A
Format: Article
Language:English
Subjects:
Bonding strength
Compressing
Disulfides
Hydrogels
Linkages
Mechanochemistry
Patterning
Utilities
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Summary:Poly(ethylene glycol) hydrogels with disulfide linkages are functionalized through applied force. Compression or tension induces bond rupture at the relatively weak disulfide linkages, which will subsequently react through Michael-type addition with an acceptor molecule within the gel. We demonstrate the utility of this approach by patterning cell adhesion proteins through compression of a lithographically structured stamp, where cells predominately adhere to the compressed regions. Poly(ethylene glycol) hydrogels with disulfide linkages are functionalized through applied force.
ISSN:2051-6347
2051-6355
DOI:10.1039/c6mh00091f