P III -Mediated intramolecular cyclopropanation and metal-free synthesis of cyclopropane-fused heterocycles

A P(NMe 2 ) 3 -mediated reductive intramolecular cyclopropanation is developed for the first time, which provides facile access to a wide variety of cyclopropane-fused heterocycles including chromanes, tetrahydroquinolines, lactones, and lactams. Catalytic hydrogenative ring-expansion of the cyclopr...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-09, Vol.56 (70), p.10251-10254
Main Authors: Zhang, Jiayong, Hao, Jiahang, Huang, Zhiqiang, Han, Jie, He, Zhengjie
Format: Article
Language:English
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Summary:A P(NMe 2 ) 3 -mediated reductive intramolecular cyclopropanation is developed for the first time, which provides facile access to a wide variety of cyclopropane-fused heterocycles including chromanes, tetrahydroquinolines, lactones, and lactams. Catalytic hydrogenative ring-expansion of the cyclopropane-fused heterocycles is also elaborated, leading to various structurally important medium-sized heterocycles.
ISSN:1359-7345
1364-548X
DOI:10.1039/D0CC04086J