Facile and direct halogenation of 1,2,3-triazoles promoted by a KX-oxone system under transition metal free conditions

A convenient and efficient oxidative halogenation of 4-aryl 1,2,3-triazoles is realized at ambient temperature under transition metal free conditions. In this methodology, halogenation is achieved by using readily available potassium halides (KBr, KCl, and KI) with oxone as an oxidant under mild rea...

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Bibliographic Details
Published in:New journal of chemistry 2021-03, Vol.45 (8), p.3969-3973
Main Authors: Rai, Vishakha, Sorabad, Ganesh Shivayogappa, Maddani, Mahagundappa Rachappa
Format: Article
Language:English
Subjects:
Ambient temperature
Chemical synthesis
Halides
Halogenation
NMR
Nuclear magnetic resonance
Oxidizing agents
Transition metals
Triazoles
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Summary:A convenient and efficient oxidative halogenation of 4-aryl 1,2,3-triazoles is realized at ambient temperature under transition metal free conditions. In this methodology, halogenation is achieved by using readily available potassium halides (KBr, KCl, and KI) with oxone as an oxidant under mild reaction conditions and halogenated products are obtained in good to excellent yields. In addition, the synthesized halogenated triazoles are applied for the synthesis of functionalized molecules. A convenient and efficient oxidative halogenation of 4-aryl 1,2,3-triazoles is realized at ambient temperature under transition metal free conditions.
ISSN:1144-0546
1369-9261
DOI:10.1039/d0nj05170e