Solubility improvement of curcumin with amino acids

Curcumin (CUR) is used as a dietary and food supplement with medicinal properties. It has a wide range of therapeutic activities such as antioxidant, anti-inflammatory, anti-arthritis, anti-tumor, anti-hyperglycemic, anti-malarial, anti-bacterial, and antiviral properties. The low solubility of curc...

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Bibliographic Details
Published in:CrystEngComm 2021-05, Vol.23 (18), p.3398-341
Main Authors: Gunnam, Anilkumar, Nangia, Ashwini K
Format: Article
Language:English
Subjects:
Additives
Adducts
Amino acids
Antioxidants
Aqueous solutions
Arthritis
Bioavailability
Dissolution
Ethanol
Glutamine
Histidine
Hydrates
Infrared spectroscopy
Lysine
NMR
Nuclear magnetic resonance
Solubility
Stability analysis
Tryptamines
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Summary:Curcumin (CUR) is used as a dietary and food supplement with medicinal properties. It has a wide range of therapeutic activities such as antioxidant, anti-inflammatory, anti-arthritis, anti-tumor, anti-hyperglycemic, anti-malarial, anti-bacterial, and antiviral properties. The low solubility of curcumin in aqueous medium (7.8 μg mL −1 ) and low bioavailability leads to its lack of use as an oral medicine. In this work, the use of basic amino acids and their biological derivatives to improve the physicochemical properties of curcumin is described. Binary adducts of CUR with tyramine, tryptamine, arginine, asparagine, glutamine, lysine, histidine, and citrulline were characterized by spectroscopic, thermal, X-ray and microscopic techniques. The solubility and dissolution of curcumin in 40% ethanol-water solution exhibited a considerable improvement for these binary products. The use of amino acids as additives to improve the solubility of CUR in medical supplements is described. Eutectic, co-amorphous, cocrystal, and physical mixtures of curcumin with basic amino acids are prepared and characterized by PXRD, DSC, NMR, FT-IR, and SEM; solubility and dissolution improvement achieved in 40% ethanol-water system.
ISSN:1466-8033
1466-8033
DOI:10.1039/d1ce00171j