NIR-absorbing Prussian blue nanoparticles for transarterial infusion photothermal therapy of VX2 tumors implanted in rabbits

Nanomaterial-related photothermal therapy has been intensively investigated for treatment of hepatocellular carcinoma (HCC). However, owing to the low specificity to tumors and easy excretion from the systemic circulation, the low dose of photoactive nanomaterials in solid tumors severely hinders th...

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Bibliographic Details
Published in:Nanoscale 2021-05, Vol.13 (18), p.849-8497
Main Authors: Pang, Huajin, Tian, Chen, He, Genghan, Zhang, Di, Yang, Jinghong, Zhang, Qianbing, Liu, Ruiyuan
Format: Article
Language:English
Subjects:
Ablation
Animals
Biocompatibility
Carcinoma, Hepatocellular - therapy
Ferrocyanides
Humans
Immune system
Liver Neoplasms - therapy
Nanomaterials
Nanoparticles
Phototherapy
Photothermal Therapy
Pigments
Rabbits
Therapy
Tumors
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Summary:Nanomaterial-related photothermal therapy has been intensively investigated for treatment of hepatocellular carcinoma (HCC). However, owing to the low specificity to tumors and easy excretion from the systemic circulation, the low dose of photoactive nanomaterials in solid tumors severely hinders the photothermal therapy applications for HCC. Herein, an innovative strategy for transarterial infusion photothermal therapy (TAIPPT) of VX2 tumors implanted in rabbits is reported. NIR-absorbing Prussian blue nanoparticles were prepared by microemulsion methods, which demonstrate excellent photothermal therapy capacity and satisfactory biocompatibility. Prussian blue nanoparticles are transarterially infused into VX2 tumors and irradiated for photothermal therapy. TAIPPT achieves fast and efficient delivery of nanoparticles into tumors and complete ablation by one-time transarterial infusion treatment. Furthermore, TAIPPT could activate the immune cells in rabbits and inhibit distant tumors. Our findings describe a promising strategy for tumor eradication and may benefit future clinical HCC patients. An innovative strategy to transarterial infusion photothermal therapy (TAIPPT) of VX2 tumor implanted in rabbit is reported.
ISSN:2040-3364
2040-3372
DOI:10.1039/d1nr01394g