Radical-polar crossover reaction of glycine derivatives

Here we report a visible-light facilitated radical addition strategy for the preparation of various natural or unnatural α-amino acids from readily available glycine derivatives and alkenes. A key aspect in achieving this side carbon chain introduction reaction, while circumventing the well-document...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-09, Vol.6 (75), p.1378-1381
Main Authors: Ye, Youwan, Zhang, Xin, Kong, Peng, Yuan, Yong, Zhao, Xiaolong, Huo, Congde
Format: Article
Language:English
Subjects:
Amino acids
Crossovers
Glycine
Molecular chains
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Summary:Here we report a visible-light facilitated radical addition strategy for the preparation of various natural or unnatural α-amino acids from readily available glycine derivatives and alkenes. A key aspect in achieving this side carbon chain introduction reaction, while circumventing the well-documented cyclization pathway, was the employment of a radical-polar crossover strategy under redox neutral conditions. We present a visible-light facilitated radical addition method to synthesize natural and unnatural α-amino acids from readily available glycine derivatives and alkenes, using a radical-polar crossover strategy under redox-neutral conditions.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d4cc02939a