ANIPE-Cu Catalyst Enables Highly Enantioselective Markovnikov Hydroboration of α-Olefins

Abstract Asymmetric hydroboration of simple and unactivated terminal alkenes (α-olefins), feedstock chemicals derived from the petrochemical industry, has not been efficiently realized for past decades. Using a bulky ANIPE ligand, we achieved a rare example of highly enantioselective copper-catalyze...

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Bibliographic Details
Published in:Synlett 2021-04, Vol.32 (6), p.545-550
Main Authors: Cai, Yuan, Shi, Shi-Liang
Format: Article
Language:English
Subjects:
synpacts
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Summary:Abstract Asymmetric hydroboration of simple and unactivated terminal alkenes (α-olefins), feedstock chemicals derived from the petrochemical industry, has not been efficiently realized for past decades. Using a bulky ANIPE ligand, we achieved a rare example of highly enantioselective copper-catalyzed Markovnikov hydroboration of α-olefins. The chiral secondary alkylboronic ester products were obtained in moderate to good yields and regioselectivities with excellent enantioselectivities. 1 Introduction 2 Conditions Optimization 3 Substrate Scope 4 Application 5 Mechanistic Discussion 6 Conclusions and Future Directions
ISSN:0936-5214
1437-2096
DOI:10.1055/a-1288-2990